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This compound was originally isolated from the cerebral venous blood of rabbits and has since been analysed as a reference peptide in neurochemical and neuroendocrine studies

In a study in 199 people monitored for five years following a kidney stone episode, subjects who increased their fluid intake enough to maintain a urine volume of 2 L or more per day had less than half the risk of recurrence compared with those who did not (Borghi 1996)

Sex-dependent effects of bmal1-deficiency on mouse cerebral cortex infarction in response to photothrombotic stroke