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Across developmental, acute, and regional manipulations, elevated KYNA consistently reduces extracellular glutamate in both the hippocampus and prefrontal cortex [30, 74, 75, 81]

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When Single-Agent GLP-1 Therapy May Be Sufficient Most patients achieve meaningful weight losstypically 10 to 22 percent of body weight over 12 to 24 monthson a single GLP-1 medication at optimal dosing

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