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The fatigue typically improves as the body adjusts, usually resolving significantly by weeks 4-8 at any given dose

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However, a major shift occurred in November 2025 when the Trump administration negotiated MFN pricing deals with Novo Nordisk and Eli Lilly, reducing Medicare/Medicaid prices for Ozempic, Wegovy, Zepbound, and Mounjaro to approximately $245/month , with Medicare beneficiary co-pays of $50/month ( [17] ) ( [22] )