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246 SuzukiTIshiharaKMigakiHMatsuuraWKohdaAOkumuraKet al

These findings epitomize the contradictory nature of lipid peroxidation in cancer processes

(Supplementary Video 1 and Video 2)

The discovery that IDH1 and IDH2 mutations are nearly all missense mutations localized to residues R132 and R172, respectively, provides a promising biomarker for cancer diagnosis and possibly gene therapy [20, 21]