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Shimizu Laboratory Supplies, Kyoto, Japan) were acclimatized for 1 week in an air-conditioned (22 2C) room on a 12-h light/dark cycle (lights on from 7:30 to 19:30)

The test subjects administered the highest dose of Dihexa spent the most amount of time in the target quadrant compared to the groups of animals treated with scopolamine alone

[PubMed: 37385275] Loomba R, Hartman ML, Lawitz EJ, et al

In a randomized controlled trial, participants were subjected to 12% calorie restriction, and their RNA sequences showed that up-regulated genes compared to controls were mainly enrichened in pathways such as autophagy, DNA repair, circadian rhythms, and mitochondrial biogenesis, whereas the inflammatory pathways were down-regulated