semaglutide and blood in urine can cause There have been reports of kidney stones as a possible Semaglutide-associated kidney injury - PMC

The IRS family includes IRS1 and IRS2, which are key proteins in insulin receptor signaling and intracellular signal transduction (73)

According to the SmPCs for these medications, the most frequently reported gastrointestinal adverse effects include nausea, vomiting, diarrhoea, constipation, abdominal pain, abdominal distension, dyspepsia and flatulence

This pattern of regain is consistent across trials of weight-loss medications in which participants were suddenly taken off the medication without a tapering schedule (where the dose is gradually reduced over time)

Schier JG, Hoffman RS (2004): Treatment of sarin exposure