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In published phase 2 research in adults with obesity or overweight, investigational retatrutide produced dose-dependent weight reduction , with the highest-dose groups showing some of the strongest body-weight outcomes reported so far for an incretin-based agent

NRF2 gene are clustered within the DLG (43%) and ETGE (57%) motifs ( Figure 6B ), which are critical sites for the binding of Nrf2 to the Keap1 DC domain