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This aligns with the understanding that B12, as a key player in one-carbon metabolism, can influence ovarian response and embryonic development [9]

In addition, a study comparing the effects of acupuncture and metformin in obese/overweight women and thin women with IR and PCOS found that acupuncture and metformin showed similar effects in thin women with IR and PCOS, but in those of obese/overweight women, acupuncture was less effective in increasing insulin sensitivity compared to metformin [144]

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