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Serving as the first barrier for circulating molecules and cells, ECs represent the main regulators of vascular homeostasis being able to respond to environmental changes, either physical or chemical signals, by producing several factors that regulate vascular tone and cellular adhesion

Darkening of Skin and Gums: A peculiar side effect seen in about 1% of female trial participants was hyperpigmentation darkening of the gums or skin (particularly on the face and breasts)