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We therefore set out to examine whether treatment with GLP-1 receptor agonists is associated with a different incidence of rheumatic diseases compared to DPP-4 inhibitors, another common class of diabetes medications. To that end, Ibis and colleagues conducted a propensity score-matched cohort study using data from the TriNetX Analytics Network

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But the dose-response data strongly suggests that peak concentration, not just total exposure, matters for glucagon receptor activation