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When your baseline is already depleted, normal stressors feel disproportionately heavy

In vivo studies using animal models or human volunteers will be employed to investigate its effects on gastric emptying, intestinal transit, and colonic motility

436 Recent work reveals that some Zur proteins harbor a pair of regulatory Zn II sites distinct from the central HHxHx 2 Cx 2 C motif ( vide supra ) that stabilizes an oligomeric assembly of three or more Zur dimers on the promoters of genes encoding cognate metal efflux transporters, leading to RNA polymerase recruitment and activation of transcription when metal levels become very high