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Adverse Pregnancy Outcomes During pregnancy, high Hcy can cause complications like high blood pressure (e.g., preeclampsia), repeated miscarriages, birth defects, and premature birth

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Basement membrane thickening and microangiopathy further restrict blood supply and oxygen delivery, causing tissue hypoxia and impeding healing

Consistent with this, our findings showed that DON induced profound redox imbalance, evidenced by the accumulation of reactive oxygen species (ROS) and the lipid peroxidation product malondialdehyde (MDA), concurrent with depletion of key antioxidants (e.g., glutathione, GSH) and reduced activities of superoxide dismutase (SOD) and catalase (CAT)