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These actions involve upregulation of TIMP-1 (tissue inhibitor of metalloproteinase) and MMP-2 (matrix metalloproteinase), both key factors in tumor metastasis (517)

Thus, the disruptions of the kidney-brain axis contribute to the high morbidity of neurological disorders, such as cognitive impairment in CKD (Yan et al., 2024)

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FOLFOX is associated with the development of sinusoidal obstruction syndrome (SOS) and nodular regenerative hyperplasia (3)