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Mast cell activation syndrome, or MCAS, is an immunological condition where the mast cells in the body release excessive amounts of chemical mediators such as histamine, leading to symptoms such as hives, flushing, rashes, swelling, low blood pressure, dizziness, brain fog, breathing difficulties, and even anaphylaxis

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[13] [18] However, in a small proportion of cases (approximately 37%), nausea may be severe enough to warrant dose reduction or discontinuation of treatment