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Description

To rule out inferiority, the FDA required CVOTs to show an upper boundary risk ratio of 1.3 (post approval), utilizing a two-sided 95% confidence interval (CI), for major adverse cardiovascular events (MACE) [55]

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At present, routine use of dual therapy specifically to improve HF outcomes cannot be recommended because dedicated randomized HF trials are lacking

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Feng, Z., Tong, W

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Instead of rapid results, expect a slow and steady pace that supports long-term success

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