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While mean values for all semen parameters at all time-points remained within the normal ranges and did not meet predefined criteria for a clinically significant change (30%), 2 subjects in the dutasteride group had decreases in sperm count of greater than 90% from baseline at 52 weeks, with partial recovery at the 24-week follow-up

In T2D patients, insulin-mediated inhibition of lipolysis is thought to be impaired, thereby increasing plasma FA levels and ectopic accumulation of TAGs in key insulin sensitive tissues leading to insulin resistance (186)