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In this study, the ability of Semaglutide to promote the proliferation of bone-derived mesenchymal stem cells (BMSCs) was determined by CCK-8 kit and flow cytometry, Alkaline phosphatase (ALP) staining and alizarin red S staining showed that semaglutide increased ALP activity and the proportion of mineralised nodules during induction of osteogenesis, wound healing assay to evaluate the pro-migratory ability of semaglutide on BMSCs.Western blotting and RT-PCR showed that semaglutide promoted the mRNA and protein expression of osteocalcin (OCN) and Runt-related transcription factor 2 (RUNX2), and further determined the OCN expression level by immunofluorescence

#DiabetesResearch Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies - Diabetologia link.springer.com To view or add a comment, sign in More Relevant Posts Major milestone in diabetes-cardiovascular therapeutics The Rybelsus (oral semaglutide) tablets from Novo Nordisk have just received FDA approval to reduce the risk of major adverse cardiovascular events (MACE) including heart attack, stroke, or cardiovascular death in adults living with type 2 diabetes at elevated cardiovascular risk

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**BMI (body mass index) has become the parameter doctors use to diagnose obesity