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doi: 10.1210/clinem/dgaa926, PMID: [DOI] [PubMed] [Google Scholar] 123.Teong XT, Liu K, Vincent AD, Bensalem J, Liu B, Hattersley KJ, et al

The different second-receptor components (glucagon vs GIP) make the combination pharmacologically complex with no theoretical or preclinical rationale

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Mechanisms such as tumor hypoxia [83], defective antigen presentation [84], abnormal angiogenesis [85], and metabolic reprogramming [86, 87] contribute to an immunosuppressive TME, undermining immunotherapeutic efficacy