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Comparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patients

So, if someone with the characteristics of this treatment group takes semaglutide 2.4mg on the standard 16 week titration schedule, they can expect a (geometric) average reduction of 48.6% The way the researchers are interpreting their findings is that the average reduction in uACR is -48.6% BUT if the placebo group is a correct representation of doing nothing (and they did nothing) they could have expected their uACR to go up 7.4% over those same 24 weeks, so in theory they end up 52.1% better off based on the geometric mean

These advancements could herald the beginning of a new era of obesity management, providing real hope for effective and accessible obesity treatment

Zirngibl K and Moll UM, p53 opens the mitochondrial permeability transition pore to trigger necrosis in response to oxidative damage, in Necrotic Cell Death , H.-M