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Description

Subtle toxicities (like mitochondrial stress, hepatocellular changes, or rare vascular events) may manifest only over time

Most drugs are considered to have a negligible effect after four-to-five half-lives

Therefore, this study investigated and compared transcriptomic changes in BAT following semaglutide and tirzepatide administration in HFHFD-fed mice, aiming to elucidate their transcriptional regulatory mechanisms and assess whether BAT represents a novel therapeutic target for metabolic disorders