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The additive benefit is most pronounced in striae albae, where the microchannel access created by needling dramatically improves delivery of active agents to the dermal level that topical application cannot reach

The restorative effect in damaged diabetic nerves versus the irritative effect in healthy nerves reconciles the improve-neuropathy / cause-dysesthesia split

Cell Metab 22(6):10681077 Chen Y, Ni J, Gao Y, Zhang J, Liu X, Chen Y, Chen Z, Wu Y (2020) Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying shikonin on colon cancer patient-derived xenograft model

Adverse events A total of 50 adverse events (AEs) were reported during this trial