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It also activates satellite cells , which fuse with existing muscle fibers to repair and thicken them

2 people out of 100 who received drug X experienced a heart attack after 3 years 4 people out of 100 who received the placebo experienced a heart attack after 3 years We divide 4/100 to get the baseline absolute risk in this placebo group (often referred to as the control group), which is 4% We then divide 2/100 to get the absolute risk in the group taking the medication (often referred to as the exposure or intervention group), which is 2% To understand the relative risk, we divide the exposed group with the placebo group: 2%/4% = 50% We can then calculate the difference between 2% and 4% to understand the absolute risk, which would be 2% This means that drug X causes a 50% relative drop in the rate of heart attacks compared to the placebo group

A useful approximation to ln(2) is 0.7

In conclusion, this real-world study emulating a target clinical trial shows that among a national cohort of patients enrolled at the VHA with moderate to advanced CKD, use of GLP1-RA was associated with lower annual rate of acute healthcare utilization, lower all-cause mortality, and lower kidney events as compared to treatment with DPP4i