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pERK1/2 assays HEK293 cells stably expressing hGLP-1R were seeded at a density of 30,000 cells/well into Poly-D-Lysine coated 96-well culture plates and incubated overnight at 37C in 5% CO 2

even lower exposure beat placebo for weight loss in early trials. The 2.4 mg maintenance dose sits on the shoulder of the effect curve rather than at a hard ceiling

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity