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While both semaglutide and tirzepatide have a glucagon-like peptide-1 (GLP-1) agonist component, tirzepatide also acts as an agonist of the gastric inhibitory polypeptide (GIP) hormone

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Delayed gastric emptying and refractory GERD can lead to occult microaspiration of acidic contents, particularly in patients with OSA during sleep, without obvious choking episodes [6]