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Specifically, baseline detection of 8-OHdG (a marker of DNA oxidative damage) and ROS levels in seminal plasma or serum enables patient stratification for precise intervention: For individuals with high oxidative stress (significantly elevated 8-OHdG/ROS), L-citrulline supplementation may offer greater benefit, with dose titration and efficacy monitoring guided by dynamic changes in these biomarkers

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[DOI] [PubMed] [Google Scholar] 110.Pearce R.K.B., Owen A., Daniel S., Jenner P., Marsden C.D