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The proposed rule would be implemented at the same time as a comprehensive agenda to lower the costs of drugs, including the drug price negotiation program and increased market competition, the Biden administration wrote.

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Abbreviations CHIP clonal haematopoiesis of indeterminate potential CKD chronic kidney disease CVD cardiovascular disease CVOT cardiovascular outcomes trial DKD diabetic kidney disease DM diabetes mellitus GIP gastric inhibitory peptide GLP1 glucagonlike peptide1 GLP1R glucagonlike peptide1 receptor HFpEF heart failure with preserved ejection fraction MACE major adverse cardiovascular event NAFLD nonalcoholic fatty liver disease NASH nonalcoholic hepatosteatosis RA receptor agonist T2D type 2 diabetes 1

doi: 10.1186/s12934-017-0808-4 68 RanG.TanD.ZhaoJ.FanF.ZhangQ.WuX.et al