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Construction of further hTrxR1 variants On the basis of the information provided by the crystal structure of the complex, 3 hTrxR1 mutants were produced from the hTrxR1 U498C mutant described above (hTrxR1 W114A,U498C , hTrxR1 N419A,U498C , and hTrxR1 W407A,N418/9A,U498C )
selectively eliminated senescent skin fibroblasts in vitro and in vivo in a model of aged mice and increased the mechanical properties of skin in aged population
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doi:10.1016/S0891-5849(02)00856-0
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