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Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action

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Additionally, tumor cells with mutations in isocitrate dehydrogenase 1 (IDH1) undergo metabolic changes, leading to elevated levels of 2-hydroxyglutarate (2-HG), which inhibits the activity of GPX4, promoting the accumulation of intracellular ROS ( Figure 2 ) ( Figure 2 4.2 Inducing ferroptosis increases sensitivity to radiotherapy As the importance of ferroptosis in tumors is increasingly recognized, ferroptosis induction in tumor cells has become a hot topic in scientific research

In case of suspicion, a gastroscopy is performed and autoantibodies against parietal cells of the stomach and/or intrinsic factor are determined