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Unlike peptide agonists such as liraglutide or semaglutide, orforglipron engages a different set of receptor residues and stabilizes an active receptor conformation associated with a signaling profile broadly similar to that of GLP-1, although arising from a distinct binding mode and receptor interaction network (Cong et al., 2022)

NAFLD during a diabetic state: therapeutic approach Lifestyle modifications (dietary changes and the implementation of healthier eating patterns (such as the Mediterranean diet), as well as increased physical activity through participation in a structured exercise program) are the cornerstones for the management of individuals with NAFLD and excess adiposity