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For most patients, needle-free delivery is a key driver in choosing the oral peptide route

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

Long-term treatment planning considers the cyclical nature of many peptide protocols, potential interactions with other therapies, and the need for continued monitoring as research in this field evolves

Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters