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Common side effects with dose escalation include nausea, vomiting, constipation, and reduced appetite, typically occurring most intensely for 1-2 weeks after each dose increase before tolerating improves

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This obligation means greater scrutiny in off-label use where this includes determining if there is adequate evidence supporting the indication. To do this, before dispensing the medicine, pharmacists must: confirm with the patient that the use of the medicine for weight loss is off-label obtain informed consent from the patient about off-label use provide additional information when counselling, ensuring patients have the opportunity to ask questions