The curvature, length, and planned intercostal space for the bar(s) are critical issues, which traditionally have relied on the experience of the surgeon and the use of intraoperative template bars.[95] This may result in an inexact, handmade, and time-consuming procedure that may further lead to incorrect selection of the length and configuration of the implants.[80] Common difficulties include requiring extensive rebending, removal, and repetitive flipping of the bars intraoperatively
Some promising approaches include the following: - Garlic-derived allicin: reduces TMAO in murine models (C57BL/6 mice), suggesting anti-atherosclerotic potential ( - TMA lyase inhibitors: synthetic compounds (e.g., fluoromethylcholine, FMC) that irreversibly inhibit CutC/D (Roberts et al., 2018)
Sources & references Frontiers in Pharmacology Stable Gastric Pentadecapeptide BPC 157 and Wound Healing Seiwerth S, Milavic M, Vukojevic J, et al
Oral formulations may require longer use to achieve comparable effects