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Superoxide released into the IMS can be eliminated by a different SOD isoenzyme (Cu, Zn-SOD, or SOD1), which is found in the cytoplasm of eukaryotic cells, or scavenged by cytochrome c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)

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Drug Interactions 12.1 Interactions with Other Antihypertensive Agents Combining Metoprolol with additional blood pressure medications may intensify hypotensive effects

It works by increasing levels of dopamine and norepinephrine, two key neurotransmitters in the brain