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These processes may help prevent or delay early neurodegeneration but may not reverse or halt disease once protein aggregation and synaptic loss are well underway. Even though the trials enrolled people with early Alzheimers, Edison noted that the disease likely had been developing silently for decades

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Dihydroorotate dehydrogenase (DHODH) within mitochondria is believed to help maintain redox balance in this organelle ( 2.3 Experimental evidence for ferroptosis in OA In recent years, as our understanding of ferroptosis has deepened, numerous basic and preclinical studies have accumulated compelling evidence supporting its active role in OA pathology