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Then, the rats started to drink excessively, then to eat and repeatedly drink water for a period of a few minutes after which they regained normal behavior, drank and then ate and showed no behavioral abnormalities until their sacrifice ( Table 6 )

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 99.9% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Contractor A, Rogers C, Maron C, Henkemeyer M, Swanson GT, Heinemann SF (2002)

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