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Most published topical studies have used concentrations between 1 percent and 3 percent

Conversion of acyl-CoA to acyl-carnitine by CPT1 is the rate limiting step and CPT1 thus becomes a key regulator of the metabolism of the cell 12

Methods We investigated the effects of TIR on markers of neuronal growth (CREB and BDNF), apoptosis (BAX/Bcl2 ratio) differentiation (pAkt, MAP2, GAP43, and AGBL4), and insulin resistance (GLUT1, GLUT4, GLUT3 and SORBS1) in a neuroblastoma cell line (SHSY5Y) exposed to normal and high glucose concentration

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