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Quercetin (0.08 mg/mL) and a well without an extract sample were used as positive and negative controls, respectively, for the assay reaction

Patients with type 2 diabetes, treated with metformin alone or treated with metformin and a second OAD treatment that could be a sulfonylurea or a glinide or a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or a dipeptidyl peptidase-4 (DPP-4) inhibitor, and who were not adequately controlled with this treatment (HbA1c range 7.5% to 10% for patients previously treated with metformin alone and 7% to 9% for patients previously treated with metformin and a second OAD treatment) entered a run-in period for 4 weeks

Gomes, B.D

A gradual reduction minimizes this spike and gives your eating behavior time to re-stabilize