Anjum et al., 2012b) and Pro (Snchez et al., 2001
The UPR, which shares molecular machinery with the integrated stress response, halts cap-dependent translation, induces expression of ER chaperone proteins and can lead to death if the stress is not resolved
[PubMed] Compound 4: TB-500 Research Findings Cellular G-actin sequestration, cytoskeletal remodeling, keratinocyte and endothelial cell migration in Boyden chamber and scratch-wound assays Molecular Integrin-linked kinase (ILK) signaling, PINCH protein interactions, NF-B pathway modulation, MMP-2/MMP-9 expression in cultured fibroblasts and keratinocytes Systemic (Preclinical) Rodent models of dermal wound repair (normal, aged, and db/db diabetic), corneal injury, and cardiac ischemia-reperfusion using full-length TB4 with parallel fragment studies References (TB-500): Malinda KM, et al
Greenberg, S