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Distinguishing local from systemic IGF-1 action A recurring theme in the muscle literature is that locally produced IGF-1 generated within the muscle in response to loading or expressed from a transgene appears especially effective at supporting hypertrophy and repair, potentially through autocrine and paracrine action on nearby satellite cells and fibers

Stress is not usually a direct cause of B12 deficiency, but chronic stress can contribute to habits and body changes that make low B12 status more likely

Liu et al., 2018), with lifestyle and microbiota-based treatments specially tailored toward the specific needs of the patients could be more efficacious in the management of CKD and related complications

doi:10.1038/nature01960