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NICE guideline CG189 (Obesity: identification, assessment and management) recommends that prescription-strength orlistat 120 mg be considered for adults with a BMI of 30 kg/m or above, or 28 kg/m or above in the presence of weight-related risk factors such as type 2 diabetes or hypertension, within a structured weight management programme

Merino B, Diez-Fernandez C, Ruiz-Gayo M, Somoza B

What has changed is not the feasibility of developing drugs without complete biological knowledge, but the expectation that developers be transparent about what is and is not known, and that uncertainty be actively managed rather than minimized (ICH E9 guidance

2a), where indel mutations are unlikely to impair Alb function