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In physical dependence assay (isoniazid challenge assessed at 6, 14, 42 and 72 h after conditioning medication), when compared to diazepam non-conditioned healthy mice, in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions), whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment

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10.12688/f1000research.21571.1 F1000Research 292 WalkinshawG.WatersC

BLM-Induced Pulmonary Fibrosis in Mice Fifty male C57BL/6 mice aged eight to 9 weeks and weighing 1822 g were randomly divided into the following five experimental groups ( n = 10 per group): (I) a normal control group, (II) a BLM group, (III) a BLM+2.6 g/ml/day GHK group, (IV) a BLM+26 g/ml/day GHK group and (V) a BLM+260 g/ml/day GHK group