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Additionally, these are not components of FDA-approved drugs and have not been found safe and effective for any condition

Clinically, DR is defined as the inability to achieve negative sodium and fluid balance despite appropriate dosing ( Importantly, what is often interpreted as DR may represent insufficient drug delivery or underdosing rather than true pharmacologic resistance

Telehealth can be especially helpful for those starting retatrutide or adjusting doses, providing timely guidance without the need for in-person appointments