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While waist circumference reduction showed a modest association with cardiovascular benefit, it accounted for only 33% of semaglutide's treatment effect on major adverse cardiovascular events.[1] This suggests that the majority of cardiovascular benefit occurs through mechanisms beyond adiposity reductionincluding direct effects on inflammation, endothelial function, blood pressure, and lipid metabolism

G., Mehri, S., & Hosseinzadeh, H

(2022) reviewed the neuroscience of GLP-1 central action in Nature Reviews Drug Discovery

Prescription medication is available only after consultation with and approval by a licensed healthcare provider, if clinically appropriate