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Retatrutide acts via cell-surface incretin and glucagon receptors, whilst 5-Amino-1MQ works intracellularly by modulating enzyme activity and NAD+ metabolism

While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism team

Simao and Cancela, 2021)