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Interestingly, our findings showed that while the SCC incidence raised significantly also in younger population, the growth was significantly higher in the elderly, which is in line with the results of previous studies 22,23

Research has found that a reduction and imbalance in the diversity of gut microbiota can lead to a decrease in -glucuronidase activity, thereby reducing the conversion of estrogen and phytoestrogen into their active and circulating forms

Cell Death Dis 14 , 186 (2023)