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doi: 10.1038/s41590-024-01985-9 95 WangRLiCChengZLiMShiJZhangZet al

Even when lab values appear normal on medication, many patients still struggle with: Slowed metabolism Insulin resistance Increased fat storage Chronic inflammation Fatigue that limits physical activity These factors create a perfect storm where calorie restriction backfires, muscle mass declines, and weight loss stalls

l-Buthionine Sulfoximine (BSO) treatment of HEK293 cells