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Postmortem studies of PD brains have demonstrated microglial activation in the substantia nigra pars compacta (SNpc), characterized by increased expression of markers such as HLA-DR, CD68, and Iba-1, along with elevated production of pro-inflammatory mediators including IL-1, TNF-, IL-6, and reactive oxygen species (ROS) [73]

For example, citrus flavonoid supplementation remodeled microbial communities, increasing Bacteroidaceae abundance and upregulating sphingolipid metabolism, which enhanced mucosal barrier function and attenuated LPS-induced inflammatory signaling 93

Urology 75 , 14521458 (2010)

McNeal JE: Regional morphology and pathology of the prostate