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A recent RCT in colorectal cancer patients undergoing chemotherapy and having sleep problems showed that melatonin had significant effects on sleep quality at week 4 [71]

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Understanding whether a patient carries predispositions toward stronger or more gradual GLP-1 pathway activation can support a more informed conversation with a provider about expected timelines, tolerance, and potential dose escalation strategies

Examination of translational biomarkers in clinical samples has the potential to elucidate mechanisms of drug toxicity that have not been previously identified