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the goal of this study was to develop an AnglV-derived molecule that retained the pro-cognitive/anti-dementia activity of AnglV and Nle'-AnglV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain

To avoid a fragmented focus on weight or pregnancy rates alone, clinical intuition can be formalized into an Expected Net Utility framework: Where P represents the probability of key outcomes and w represents the patients preference weights for those outcomes