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A pharmacology that keeps amylin receptors tonically engaged, day and night, may reproduce amylins central appetite effects (which appear to tolerate sustained stimulation reasonably well) while behaving quite differently at the level of the stomach, where continuous braking could invite adaptive counter-regulation
( f ) Food intake, ( g ) RER (effect of treatment F(1,10) = 6.34 p = 0.031), ( h ) energy expenditure (with ANCOVA using BW as covariate), ( i ) ambulatory activity and ( j ) body weight change of WT mice treated with VEH or acyl-GIP ( d - j , n = 6 per group
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